Form variation in Escherichia coli K1: determined by O-acetylation of the capsular polysaccharide.
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Form variation in Escherichia coli K1: determined by O-acetylation of the capsular polysaccharide
The chemical basis for the alternating antigenic change called form variation noted for the Escherichia coli K1-capsular polysaccharide has been shown by 13C nuclear magnetic resonance to be a result of random O-acetylation of C7 and C9 carbons of the alpha-2-8-linked sialic acid homopolymer. A serologic method (antiserum agar) was developed to identify and isolate the form variants. The O-acet...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1979
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.149.3.669